Multiple Sclerosis Resource Centre

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GMSI Award 2016 – Updates on the GMSI 2013, 2014 and 2015 award winners

David Bates

This lecture was given at the Grant for Multiple Sclerosis Innovation Awards Event on September 15, 2016 in London. The GMSI award is sponsored by Merck KGaA, Darmstadt, Germany.

In this session, Prof Bates highlights a few of the many projects that are contributing positively to MS research through the GMSI program. Some interesting results are forthcoming from a sound localisation system used to look at brainstem lesions in early disease by Joshua Bacon. Kevin O’Connor is doing some innovative work into discovering that B-cells come from the brain into the cranial lymphatics and into circulation. Maria Domercq and Carlos Matute are working on re-educating microglia to eliminate their pro-inflammatory M1 functions and promote their M2 phagocytic and regenerative function to enhance remyelination. Bruno Stankoff is working on developing and assessing a new imaging biomarker to potentially be used as an index of neurodegeneration. He will combine PET, a radiofluorinated form of Flumazenil and MRI to investigate the pathophysiology of this neuronal damage. Elga de Vries is investigating the dynamics of M1/M2 polarisation of microglia using PET imaging to formulate a diagnostic tool.

Professor David Bates, Newcastle University, UK