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GMSI Award 2016 – Award Winner Elena Martinez-Lapiscina and colleagues

Elena Martinez-Lapiscina

This lecture was given at the Grant for Multiple Sclerosis Innovation Awards Event on September 15, 2016 in London. The GMSI award is sponsored by Merck KGaA, Darmstadt, Germany.

Raman spectroscopy (RS) of the retina may add important biomarkers for clinical use. RS is a laser-based technique that measures molecular changes; its use in MS patients is novel as it has only been used in tissues and animal models to date. Preliminary data from mice shows that RS can effectively track inflammatory changes in tissue. Two pilot studies have shown: 1) reproducibility of the technique in healthy volunteers, and 2) an ability to identify molecular signatures in the retinas of MS patients versus healthy volunteers. In this project, healthy volunteers and MS patients will be recruited. Step 1 will be to define the molecular signature in MS and its phenotypes, and Step 2 will be to quantify and compare the concentrations of key metabolites with several clinical signs such as inflammation and axonal injury. Model validation will follow. Outcomes are to help define optimal patient populations for clinical trials, to define molecular targets, and to develop markers that help identify failed therapies.

Dr Elena H Martinez-Lapiscina, IDIBAPS-Hospital Clinic, Barcelona, Spain