Multiple Sclerosis Resource Centre

Welcome to the Multiple Sclerosis Resource Centre. This website is intended for international healthcare professionals with an interest in Multiple Sclerosis. By clicking the link below you are declaring and confirming that you are a healthcare professional

You are here

Non-Significant Associations Between Measures of Inhibitory Control and Walking While Thinking in Persons with Multiple Sclerosis

Archives of Physical Medicine and Rehabilitation

Abstract

Objective

The current study examined if inhibitory control measures were associated with the dual-task cost (DTC) of walking in 28 persons with multiple sclerosis (MS) and 28 matched controls without MS.

Design

Cross-sectional study

Setting

University research laboratory

Participants

The sample included 28 ambulatory persons with relapsing-remitting MS (median Expanded Disability Status Scale score = 3.0) from the local community (26 female, 2 male) and 28 controls matched by age, sex, body mass index, and education.

Interventions

N/A

Main Outcome Measures

All participants underwent a modified flanker task followed by four trials of the timed 25-foot walk. The first two trials involved walking as quickly as possible only (single-task condition), and the second two trials involved walking as quickly as possible while naming alternate letters of the alphabet (dual-task condition). Walking speed under single- and dual-task conditions was used to compute a DTC of walking.

Results

Persons with MS demonstrated a similar DTC of walking compared with matched controls, but performed more poorly on inhibitory control measures. Interestingly, inhibitory control measures were not associated with DTC of walking in the MS sample (all |ρ|<.26,p>.19), but were associated with DTC of walking in controls (all |ρ|>.42,p<.03).

Conclusions

Inhibitory control based on modified flanker performance might not be associated with DTC of walking in persons with MS.

Keywords: Dual Task, Walking, Cognition, Multiple Sclerosis, Executive Control, Cognitive Processing Speed, Inhibitory Control, T25FW.

Abbreviations: ANOVA - analysis of variance, BMI - body mass index, CMI - cognitive-motor interference, CoV - Coefficient of Variation, CPS - cognitive processing speed, DTC - dual-task cost, EDSS - Expanded Disability Status Scale, MS - multiple sclerosis, MSNQ - Multiple Sclerosis Neuropsychological Questionnaire, NIH - National Institutes of Health, SDMT - Symbol Digit Modalities Test, T25FW - timed 25-foot walk.

Footnotes

1 Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign

2 Department of Neurology, University at Buffalo, State University of New York

Correspondence to Robert W. Motl, University of Illinois at Urbana-Champaign, Department of Kinesiology and Community Health, 233 Freer Hall, 906 South Goodwin Ave., Urbana, IL, 61801, USA, phone 1-217-265-0886, fax 1-217-244-7322.

Disclosure: Dr. Benedict reports grants and personal fees from Biogen Idec, grants and personal fees from Novartis, grants and personal fees from Genzyme, personal fees from Genentech, personal fees from EMD Serono, grants from Accorda, and grants from Questcor outside the submitted work; In addition, Dr. Benedict has a patent with Psychological Assessment Resources with royalties paid.


Search this site

Stay up-to-date with our monthly e-alert

If you want to regularly receive information on what is happening in MS research sign up to our e-alert.

Subscribe »

About the Editors

  • Prof Timothy Vartanian

    Timothy Vartanian, Professor at the Brain and Mind Research Institute and the Department of Neurology, Weill Cornell Medical College, Cornell...
  • Dr Claire S. Riley

    Claire S. Riley, MD is an assistant attending neurologist and assistant professor of neurology in the Neurological Institute, Columbia University,...
  • Dr Rebecca Farber

    Rebecca Farber, MD is an attending neurologist and assistant professor of neurology at the Neurological Institute, Columbia University, in New...

This online Resource Centre has been made possible by a donation from EMD Serono, Inc., a business of Merck KGaA, Darmstadt, Germany.

Note that EMD Serono, Inc., has no editorial control or influence over the content of this Resource Centre. The Resource Centre and all content therein are subject to an independent editorial review.

The Grant for Multiple Sclerosis Innovation
supports promising translational research projects by academic researchers to improve understanding of multiple sclerosis (MS) for the ultimate benefit of patients.  For full information and application details, please click here

Journal Editor's choice

Recommended by Prof. Brenda Banwell

Causes of death among persons with multiple sclerosis

Gary R. Cutter, Jeffrey Zimmerman, Amber R. Salter, et al.

Multiple Sclerosis and Related Disorders, September 2015, Vol 4 Issue 5