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Safety and efficacy of fingolimod in clinical practice: The experience of an academic center in the middle east

Bassem I. Yamout, Maya M. Zeineddine, Hani Tamim, Samia J. Khoury

Journal of Neuroimmunology, Volume 289, 15 December 2015, Pages 93–97

Highlights
 

  • Fingolimod is an oral agent with proven efficacy and safety in multiple sclerosis.
  • Our cohort of 122 patients confirms its effectiveness in a real world setting.
  • The most common adverse events were lymphopenia, increase liver enzymes, urinary tract infections and fatigue.

Abstract
 

Background

Few published studies addressed real-world clinical experience with fingolimod especially in the Middle East region.

Objective

To review our clinical experience with fingolimod at a specialized academic MS center in Lebanon.

Methods

All patients treated with fingolimod at the MS Center between October 2011 and January 2015 were retrospectively identified.

Results

A total of 122 patients were included. The first dose observation was uneventful in 98.8% of patients. Annualized relapse rate decreased from 1.16 pre-treatment to 0.29 post-treatment representing a relative risk reduction of 75% (p < 0.0001). The proportion of patients with no new T2 or enhancing lesions was 66.3%. Seventy-six (62.3%) patients experienced adverse events with lymphopenia, increase liver enzymes, urinary tract infections and fatigue being the most common.

Conclusion

Our cohort confirms the effectiveness and safety of fingolimod in a real world setting


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About the Editors

  • Prof Timothy Vartanian

    Timothy Vartanian, Professor at the Brain and Mind Research Institute and the Department of Neurology, Weill Cornell Medical College, Cornell...
  • Dr Claire S. Riley

    Claire S. Riley, MD is an assistant attending neurologist and assistant professor of neurology in the Neurological Institute, Columbia University,...
  • Dr Rebecca Farber

    Rebecca Farber, MD is an attending neurologist and assistant professor of neurology at the Neurological Institute, Columbia University, in New...

This online Resource Centre has been made possible by a donation from EMD Serono, Inc., a business of Merck KGaA, Darmstadt, Germany.

Note that EMD Serono, Inc., has no editorial control or influence over the content of this Resource Centre. The Resource Centre and all content therein are subject to an independent editorial review.

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supports promising translational research projects by academic researchers to improve understanding of multiple sclerosis (MS) for the ultimate benefit of patients.  For full information and application details, please click here

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