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Multiple sclerosis: clinical characteristics and disability progression in Moroccan children

Elhachmia Ait Ben Haddou, Mounia Alhyan, Jehanne Aasfara, Wafa Regragui, Azeddine Ibrahimi, Rachid Razine, Redouane Abouqal, Ali Benomar, Mohamed Yahyaoui

Journal of the Neurological Sciences, Available online 13 August 2014

Background
5% of multiple sclerosis have their onset in childhood.

Objectives
We aim to show the clinical features and follow-up of Moroccan pediatric MS patients.

Methods
25 pediatric MS records were analyzed between 2005 and 2013 at the Neurology B department of Rabat Ibn sina University Hospital and Medical School Group of Neurogenetic Disorder of Rabat Mohammed V University Souissi.

Results
The median duration of follow up was 4 years [1.56]. The median age at disease onset was 14 years. Clinical symptoms were described. At the last evaluation, the median EDSS score was 3.0 [0–7.5]. The median time between disease onset and diagnosis was 2 years [1–9] and the median time from MS onset to second neurological episode was 1 year [0.9–3] with an average of 2 relapses in the first 2 years. The median time to reach EDSS 3.0 was 4.5 years [2–17] and the median time to go from EDSS 3.0 to 6.0 was 4 years [2.5–6]. The majority of cases at the last follow-up were; relapsing–remitting (17 patients: 68%), although 8 patients (32%) developed secondary progressive MS after median disease duration of 5 years [4–19]. None of the patients had a primary progressive MS.

Conclusion
Time EDSS 3.0 and to secondary progression was shorter in our cohort than previously reported in other series.

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About the Editors

  • Prof Timothy Vartanian

    Timothy Vartanian, Professor at the Brain and Mind Research Institute and the Department of Neurology, Weill Cornell Medical College, Cornell...
  • Dr Claire S. Riley

    Claire S. Riley, MD is an assistant attending neurologist and assistant professor of neurology in the Neurological Institute, Columbia University,...
  • Dr Rebecca Farber

    Rebecca Farber, MD is an attending neurologist and assistant professor of neurology at the Neurological Institute, Columbia University, in New...

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Multiple Sclerosis and Related Disorders, September 2015, Vol 4 Issue 5