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Long-distance effects of inflammation on differentiation of adult spinal cord neural stem/progenitor cells

Lisa Arvidsson, Ruxandra Covacu, Cynthia Perez Estrada, Sreenivasa Raghavan Sankavaram, Mikael Svensson, Lou Brundin

Journal of Neuroimmunology, Volume 288, 15 November 2015, Pages 47-55


  • NPCs derived from NASC parts of EAE rats are affected by distant inflammation.
  • NPCs from NASC are less prone to generate oligodendrocytes than control NPCs.
  • NPCs from NASC are more neurogenic than NPCs from control rats


Studies in multiple sclerosis have demonstrated that normal-appearing white matter can harbor pathological changes. Here we investigated the effects of neuroinflammation, modeled by experimental autoimmune encephalomyelitis (EAE) on neural stem/progenitor cells (NPCs) located distally to inflammatory foci. We observed that EAE-derived NPCs had a lower capacity to differentiate into oligodendrocytes and an increased neuronal differentiation than control NPCs. This finding was corroborated with changes in gene expression of early differentiation genes. We conclude that inflammation has a long range effect on the NPCs in the diseased central nervous system, reaching NPC populations outside the lesion sites.

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About the Editors

  • Prof Timothy Vartanian

    Timothy Vartanian, Professor at the Brain and Mind Research Institute and the Department of Neurology, Weill Cornell Medical College, Cornell...
  • Dr Claire S. Riley

    Claire S. Riley, MD is an assistant attending neurologist and assistant professor of neurology in the Neurological Institute, Columbia University,...
  • Dr Rebecca Farber

    Rebecca Farber, MD is an attending neurologist and assistant professor of neurology at the Neurological Institute, Columbia University, in New...

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