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Increased natural killer cell chemotaxis to CXCL12 in patients with multiple sclerosis

Esther Serrano-Pertierra, Miguel A. Blanco-Gelaz, Pedro Oliva-Nacarino, Pablo Martínez-Camblor, Javier Villafani, et al.

Journal of Neuroimmunology, Volume 282, 15 May 2015, Pages 39-44


  • We designed transwell migration assays coupled to six-color flow cytometry.
  • Chemotaxis of four lymphocyte subsets was analyzed in MS and CIS patients.
  • NK cell migration is increased in patients in remission and CIS patients.
  • The frequency of NK cells expressing CXCR4 is higher in these patients.


Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized by leukocyte infiltration into the central nervous system (CNS). Migration of lymphocyte subpopulations towards CXCL12 was analyzed coupled to six-color flow cytometry in untreated patients in the remitting phase, during relapse, in patients with clinically isolated syndrome (CIS), and in healthy volunteers. Significantly higher migration rates of natural killer cells (CD45+CD3−CD16/56 +) were observed in patients in remission and CIS patients than in patients during relapse and in controls. Moreover, the frequency of CD3−CD16/56+CXCR4 + cells is higher in patients in remission and in CIS patients, but not during relapse.

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About the Editors

  • Prof Timothy Vartanian

    Timothy Vartanian, Professor at the Brain and Mind Research Institute and the Department of Neurology, Weill Cornell Medical College, Cornell...
  • Dr Claire S. Riley

    Claire S. Riley, MD is an assistant attending neurologist and assistant professor of neurology in the Neurological Institute, Columbia University,...
  • Dr Rebecca Farber

    Rebecca Farber, MD is an attending neurologist and assistant professor of neurology at the Neurological Institute, Columbia University, in New...

This online Resource Centre has been made possible by a donation from EMD Serono, Inc., a business of Merck KGaA, Darmstadt, Germany.

Note that EMD Serono, Inc., has no editorial control or influence over the content of this Resource Centre. The Resource Centre and all content therein are subject to an independent editorial review.

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supports promising translational research projects by academic researchers to improve understanding of multiple sclerosis (MS) for the ultimate benefit of patients.  For full information and application details, please click here

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Multiple Sclerosis and Related Disorders, September 2015, Vol 4 Issue 5