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Contributing factors in multiple sclerosis and the female sex bias
Immunology Letters, Available online 16 September 2014
Autoimmune diseases, such as multiple sclerosis (MS), show a higher incidence rate in women compared to men, which may be due to differences in the immune system, sex hormones, or both. Furthermore a disruption in homeostasis within these systems appears to be contributing to the etiology of MS. These systems are also influenced by the environment and metabolic factors necessitating the adoption of a broader viewpoint of the contributing factors in MS in the search for effective therapeutics.
Multiple Sclerosis; T cells; Sex bias; Endocrine system; Immune system; Environment; Adipokines;Adenosine