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Analysis of apoptosis-related genes in patients with CIS and their association with conversion to MS

Sanna Hagman, Marcin Kolasa, Pabitra Basnyat, Mika Helminen, Mika Kähönen, et al.

Journal of Neuroimmunology, Volume 280, 15 March 2015, Pages 43-48


  • To analyse apoptosis-related genes associated with conversion from CIS to MS.
  • Eleven candidate genes were studied in CIS patients over a four-year follow-up period.
  • No association between the expression of these genes and conversion was found.
  • Variability in the genes was linked to TGFB1 levels in converting patients.
  • These events may reflect immune activation that seems to play a role in MS.


To analyse whether the expression of apoptotic transcripts is associated with the conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS). Eleven candidate transcripts belonging to the death receptor pathway, BCL-2, the inflammasome complex and NF-ΚB family were studied in the nonconverting and converting CIS patients during the four-year follow-up period. Conversion to MS was associated with marked variability in the expression of proapoptotic genes that were linked to TGF-B1 gene levels. The predominant expression of proapoptotic genes in patients with CIS suggests an increased potential to undergo apoptosis with the goal of terminating immune responses and regulating immune system homeostasis.

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About the Editors

  • Prof Timothy Vartanian

    Timothy Vartanian, Professor at the Brain and Mind Research Institute and the Department of Neurology, Weill Cornell Medical College, Cornell...
  • Dr Claire S. Riley

    Claire S. Riley, MD is an assistant attending neurologist and assistant professor of neurology in the Neurological Institute, Columbia University,...
  • Dr Rebecca Farber

    Rebecca Farber, MD is an attending neurologist and assistant professor of neurology at the Neurological Institute, Columbia University, in New...

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