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MicroRNAs associated with the pathogenesis of multiple sclerosis
Qingrong Huang, Bo Xiao, Xinting Ma, Mingjuan Qu, Yanmin Li, Prakash Nagarkatti, Mitzi Nagarkatti, Juhua Zhou
- Specific patterns of dysregulated mRNAs are presented in immune cells and brain tissues from multiple sclerosis patients.
- Specific miRNAs play a critical role in the pathogenesis of multiple sclerosis.
- miRNAs may be used as potential biomarkers for diagnosis of MS and therapeutic targets for MS treatment.
- miRNAs may potentially be used as prediction markers for the responses to MS treatment.
Multiple sclerosis (MS) is not only an autoimmune disease in which autoreactive immune cells against myelin damage axons and nerves in the central nervous system, but also a neurodegenerative disease, in which progressive loss of structure and function of neurons occurs. The mechanisms of MS pathogenesis have not been fully understood. It has been reported that miRNAs may play a critical role in MS pathogenesis. In this review, we have extensively discussed the alterations in the expression of miRNAs detected in patients with MS. The dysregulated miRNAs have been shown to be associated with the pathogenesis of MS. We suggest that such dysregulated miRNAs may potentially be used as biomarkers in the diagnosis of MS, to discover new therapeutic targets for MS treatment, and to predict prognostic markers in responses to MS treatment.